People with Sickle Cell anaemia have greater than average requirements for both calories and micro-nutrients. A diet emphasizing fruits, vegetables, whole grains and legumes will provide a greater proportion of essential nutrients than a typical Western diet, while appropriate supplementation – one to three times the recommended intakes for most essential nutrients – can prevent deficiency and may decrease the likelihood of disease exacerbation. This is how to manage sickle cell disease with recommended vitamins below.